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Lung cancer expert Dr. Joseph Leach provides an overview of how lung cancers with EGFR mutations are treated. The good news is that specific treatments can target EGFR mutations. Dr. Leach talks about targeted therapies including osimertinib (for exon 19 and exon 21 mutations), amivantamab (for an exon 20 insertion mutation), and others. He also discusses chemotherapy. Cancer cells with EGFR mutations can become resistant to treatment, so it is important to repeat biomarker testing if treatment stops working at any time. A different drug can make treatment more effective again.